Interestingly, while HIF1α and HIF2α expression in ccRCC exhibited an opposed behavior (Fig. 7), the increased expression of either HIF1α or HIF2α in ccRCC appears to be associated with a favorable patient survival rate (Fig. 8), although in the case of HIF1α, it is not significant (Fig. 8A). The gene discussed is EPAS1; the disease is nonpapillary renal cell carcinoma.