For example, in terms of MCL-1 as a prognostic biomarker, analysis of Bcl-2, Bax, and MCL-1 expression in 185 chronic lymphocytic leukemia (CLL) patients, authors found that MCL-1 expression was significantly correlated with stage of disease, lymphocyte doubling time, Ig VH gene mutation status, CD38 expression, and ZAP-70 expression [46]. This evidence concerns the gene ZAP70 and B-cell chronic lymphocytic leukemia.