Patient survival probability analysis of the individual RCC patient cohorts indicated that the TP53/p53 mutation is clearly associated with poor patient survival in all three major RCC types (Fig. 14), even though only a low-level somatic mutation of TP53/p53 in KIRC/ccRCC and KIRP/pRCC (Supplemental Table S2). This evidence concerns the gene TP53 and renal cell carcinoma.