CASP2 and acute myeloid leukemia: 4f downregulated NRF2 protein, had a profound growth-inhibitory effect on all three acute myeloid leukemia (AML) cell lines tested (THP-1, HL-60 and U937), and induced apoptosis, which was evidenced by flow cytometry, caspase-2 cleavage and PARP cleavage [107].