BIRC5 and nonpapillary renal cell carcinoma: Interestingly, Parker et al. used immunohistochemistry (IHC) to determine the expression level of B7-H1, survivin, and Ki-67 for 634 consecutive ccRCC patients and then combined the 3 independent predictors of ccRCC outcomes into a single scoring panel termed as “BioScore” with the hopes to refine outcome prediction [27].