However, due to the use of different mechanisms for the TGase2-mediated degradation of p53 (p53 into autophagosome) versus MDM2-mediated degradation of p53 (via p53 ubiquitination), depletion of either of TGase2 or MDM2 induced p53 stabilization in RCC cells [159]. The gene discussed is TGM2; the disease is renal cell carcinoma.