A recent report indicated that while p53 stability in RCC was inversely related to the expression level of MDM2 and Transglutaminase 2 (TGase2, a protein involved in autophagic protein degradation), inhibition of TGase2 but not MDM2 in an in vivo RCC model had efficient anticancer effects [120]. Here, TP53 is linked to renal cell carcinoma.