Furthermore, a follow-up study showed that PT2385 inhibited HIF2 in nontumor tissues in all but one patient, who had the lowest drug concentrations; PT2385 dissociated HIF2 complexes even in ccRCC metastases, and inhibited HIF2 target gene expression; in contrast, HIF1 complexes were unaffected [83]. Here, HIF1A is linked to nonpapillary renal cell carcinoma.