MDM2 and renal cell carcinoma: Interestingly, this study indicated that there is no association between age at tumor onset and MDM2-SNP309 genotypes from the analysis of the entire RCC cohort or among the male RCC patients, the female GG patients (median age 59.5 years) were diagnosed 13.5 years earlier than the TT females (median age 73 years) [117].