Nevertheless, we have sorted pRCC tissue samples and normal tissues into Type 1 and Type 2 pRCC (Supplemental Table S3), the expression of NRF2 in Type 1 pRCC has no significant difference, and in Type 2 pRCC has a marginal significance of NRF2 expression decrease in tumor tissues versus normal tissues (Supplemental Figure S1A). This evidence concerns the gene NFE2L2 and neoplasm.