In the case of AKT2, while the expression of AKT2 is significantly decreased in the early stage 1 of chRCC and ccRCC (Supplemental Figure S5), none of the AKT2 low versus high expression in ccRCC, chRCC or pRCC is associated with a patient survival difference (Supplemental Figure S6). Here, PRCC is linked to chromophobe renal cell carcinoma.