NPTX2 and Alzheimer disease: We then overlapped these DE proteins in CSF with the brain proteome (Supplementary Table S2), yielding a core table of 65 upregulated proteins (e.g. MAPT, SMOC1, HTRA1, PDLIM5, PRDX6, RUVBL2, CALB2, ARFGAP3, SPP1 and DPCD) and 44 downregulated proteins in AD (e.g. NPTX2, VGF, PDHA1, NDUFV1, NDUFA2, NDUFA12, NDUFA13, NDUFS3, ATP5B and ATP5J, Supplementary Table S5).