Higginbotham et al. also used immunodepletion to enhance the depth of CSF proteome, profiled 2,875 proteins from 20 control and 20 AD cases, revealing 528 DE proteins, including MAPT, NEFL, GAP43, FABP3, CHI3L1, NRGN; VGF, GDI1 and SMOC1 [75]. The gene discussed is MAPT; the disease is Alzheimer disease.