Interestingly, the DE list contains 35 reported AD genes and risk loci, including APP, MAPT, CLU, APOE, ICA1, PTK2B, CD2AP, SNX32, ADAM17, FERMT2, CARHSP1, ANK3, ABI3, PLEKHA1, BCKDK, GRN, COX7C, TMEM163, CNTNAP2, ADAMTS1, NDUFAF7, SEL1L, RTFDC1, AGRN, ICA1L, SPRED2, HLA-DRB1, INPP5D, TPBG, PLCG2, IDUA, CTSH, PRKCH, PFDN1, and SHARPIN (Supplementary Table S1, ranked by protein false discovery rate). The gene discussed is MAPT; the disease is Alzheimer disease.