We then overlapped these DE proteins in CSF with the brain proteome (Supplementary Table S2), yielding a core table of 65 upregulated proteins (e.g. MAPT, SMOC1, HTRA1, PDLIM5, PRDX6, RUVBL2, CALB2, ARFGAP3, SPP1 and DPCD) and 44 downregulated proteins in AD (e.g. NPTX2, VGF, PDHA1, NDUFV1, NDUFA2, NDUFA12, NDUFA13, NDUFS3, ATP5B and ATP5J, Supplementary Table S5). The gene discussed is SPP1; the disease is Alzheimer disease.