The risk factors for histoplasmosis were pancytopenia (OR 4.1, 95 CI 1.6–10.3, P = 0.002), < 50 CD4 + cells/μL (OR 3.1, 95 CI 1.3–7.3, P = 0.006) and Aspartate transaminase (AST) levels > 46 IU/L (OR 3.2, 95 CI 1.3–8, P = 0.01). This evidence concerns the gene CD4 and Pancytopenia.