The G allele of rs2023239 of CNR1 is linked with higher cortical CBR1 and is associated with smaller hippocampal volume in chronic cannabis users, but not healthy controls and findings that suggest only individuals with a high genetic risk of schizophrenia experience a negative impact on cortical maturation during early adolescence thus suggestive of gene × drug interactions [56–58]. Here, CNR1 is linked to schizophrenia.