TNF and cancer: Moreover, the enrichment analysis of KEGG pathway showed that the module genes were enriched in ECM-receptor interaction, protein digestion and absorption, focal adhesion, PI3K-Akt signaling pathway, pathways in cancer, cytokine–cytokine receptor interaction, TNF signaling pathway, NOD-like receptor signaling pathway, chemokine signaling pathway, Toll-like receptor signaling pathway, platelet activation, mismatch repair, and RIG-I-like receptor signaling pathway (Fig. 5).