The loss of CSMD1 ﻿has been found to be associated with enhanced cell proliferation, migration and poor prognosis in head and neck squamous cell carcinoma (HNSCCs), lung squamous cell carcinoma (SCCs), melanoma, and breast cancer, suggesting its role as a tumor suppresser [9–11]. This evidence concerns the gene CSMD1 and head and neck squamous cell carcinoma.