On the other hand, IL-6 and ACE2 were found to be successful in classifying COVID-19 patients with headache (SeIL-6: 0.82; SpIL-6:0.48) (SeACE2: 0.79; SpACE2: 0.53), while NLRP3 was successful in classifying COVID-19 patients without headache (SeNLRP3: 0.38; SpNLRP3:0.93). This evidence concerns the gene ACE2 and Headache.