BCL6 and diffuse large B-cell lymphoma: BCL6 negative(PFS: HR=1.652, 95% CI 1.030–2.649, P=0.037), P53 positive(OS: HR=1.842, 95% CI 1.008–3.367, P=0.047), and BCL2 strong positive expressions(S +)(OS: HR=2.102, 95% CI 1.249–3.537, P=0.005; PFS: HR=2.126, 95% CI 1.312–3.443, P=0.002)are adverse prognostic factors of DLBCL that are independent of IPI.