In conclusion, our study identified 13 hub genes and 3 non-hub genes (AURKA, CCNB1, BUB1B, PRC1, TPX2, NUSAP1, TOP2A, KIF20A, KIF2C, RRM2, ASPM, PPARG, non-hub genes are CDCA3, ZWINT and UBE2S) that might be involved in the progression of BC using multiple gene expression data sets and a series of comprehensive analyses of bioinformatics. This evidence concerns the gene TOP2A and breast cancer.