CASP3 and lung carcinoma: Fig 5 respectively indicate the alteration of apoptosis maker proteins in human lung cancer A549 and H460 cells cultured with 10–50 μM norcycloartocarpin. The correspondent increase of activated caspase3 (Cleaved caspase-3) and degraded form of its substrate, cleaved PARP, was obviously noticed in the cells treated with 50 μM norcycloartocarpin for 24 h (Fig 5A–5D). Moreover, there was the higher expression of cleaved caspase-9, an initiator caspase in A549 and H460 cells after incubation with norcycloartocarpin at 25 and 50 μM as presented in Fig 5A and 5B, respectively.