The downregulation of Ltbp2 induced by elevated sEV-carried miR-20a-3p or decreased sEV miR-186 and miR-324-5p in patients with HIV lipodystrophy may underlie the impairment of adipose tissue development/differentiation and the increased activation of inflammatory processes seen in such patients and could be a potential target for future clinical studies (Figure 9). The gene discussed is LTBP2; the disease is lipodystrophy.