CCN5 and partial lipodystrophy: In this study, we determined that knockdown of Ltbp2 and Wisp2 resulted in significant downregulation of Lamin C. The Lmna gene encodes both lamins A and C — isoforms generated by alternative splicing of Lmna. Lmna gene mutations generally disrupt both lamin A and lamin C in partial lipodystrophy (42).