Moreover, high-intensity interval training improves the preserved left ventricular ejection fraction induced by high-salt stress, and the mechanism is that High-intensity interval training reverses the endothelial dysfunction such as nicotinamide adenine dinucleotide phosphate-oxidase, endothelial nitric oxide synthase, and advances glycation end product induced by high-salt stress [60]. The gene discussed is NOS3; the disease is endothelial dysfunction.