2015). Proteomics results of TMT and PRM both show that Hsp90α is up-regulated in CUMS group and down-regulated in CUMS + JWSNS group. Hsp90 is widely expressed in all regions of the adult mammalian nervous system and preferentially localized on neurons (D’Souza and Brown 1998). Most studies have shown that Hsp90 is involved in neurodegenerative diseases, neuron differentiation and axon outgrowth (Benitez et al. 2014). Here, HSP90AA1 is linked to neurodegenerative disease.