GOPC and Anxiety: We detected no difference between genotypes during the 2 min after mice received the first footshock (FEM WT = 4.9 ± 1.6; FEM KO = 6.6 ± 3.2; MALE WT = 20.1 ± 5.6; MALE KO = 19.8 ± 5.7), indicating that anxiety toward the context and pain sensitivity, respectively, are unchanged in Gopc KO mice.