VEGFA and cancer: The association between platelet count and cancer is complex and involves inflammation, wound healing, angiogenesis, and the maintenance of vascular integrity.6,7,8 Platelet granules contain many cytokines, angiogenic factors, bioactive lipids, and mediators of angiogenesis that are released upon platelet activation.6 Platelets are the largest repository of vascular endothelial growth factor in the blood.15