Furthermore, overexpression of CDK1,[78]CCNB1,[79] peroxiredoxin 3 (PRDX3),[80]TOP2A,[81]SPC25,[82]CDKN3,[83]KIF4A,[84]TTK,[85] POU class 5 homeobox 1 (POU5F1),[86] and TPX2[87] has been reported to play a role in CRC. This evidence concerns the gene POU5F1 and colorectal carcinoma.