CFTR and cystic fibrosis: In order to determine if WT SMase similarly inhibited CFTR‐mediated transepithelial current and conductance in cells from people with CF, and to determine if current FDA‐approved CFTR modulators could overcome WT SMase‐mediated inhibition of CFTR, these experiments were repeated on cfHBEs homozygous for the ΔF508‐CFTR mutation.