Recent evidence from multiple laboratories using multiple methods, including thin layer chromatography and mass spectrometry, has indicated that ceramides are increased in polarized bronchial epithelial cells from people living with CF (homozygous or heterozygous for the ΔF508‐CFTR mutation), as compared to cells from non‐CF subjects (Gardner et al., 2020; Loberto et al., 2020). Here, CFTR is linked to cystic fibrosis.