Moreover, signal lymphocyte activation molecule (SLAM)F7 expressed on tumor‐associated macrophages (TAMs) could activate the self‐ligand SLAMF7 on T cells in RCC, which could promote the phosphorylation of STAT1/3 and upregulate the expression of costimulatory molecules, such as PD‐1 and T cell exhaustion‐related transcription factors. The gene discussed is PDCD1; the disease is neoplasm.