The dysfunction of PBRM1 in approximately 41% of patients with RCC also significantly induced the enrichment of IL‐6/JAK‐STAT and immune‐stimulating signals, which could upregulate IFN‐γ expression and may promote the formation of immune‐stimulating microenvironment, thereby improving the response to PD‐1/PD‐L1 mAbs.135, 136. Here, CD274 is linked to renal cell carcinoma.