According to the existing mechanisms affecting PD‐L1 expression in RCC, constitutive PD‐L1 overexpression and PD‐L1 overexpression induced by long‐term tumor neoantigen stimulation may be associated with poor response, while tumor cells stimulated by the immune microenvironment promote the secretion of inflammatory cytokines, such as IFN‐γ and IL‐1β, thus inducing adaptive PD‐L1 overexpression, which is related to enhanced response. The gene discussed is IFNG; the disease is neoplasm.