However, the interaction of HLA‐G expressed by tumor cells and ILT2 could significantly inhibit the effector function of TILs, and ILT2 blockade could rescue this inhibition,108 indicating the possibility of the combination of HLA‐G/ILT2 blockade and PD‐1/PD‐L1 blockade. This evidence concerns the gene LILRB1 and neoplasm.