Thousands of differential methylation sites associated with RA have been observed in nearly a decade of EWASs.[84, 85, 86] The human major histocompatibility complex (MHC) has a strong epigenetic association with the pathogenesis of RA.[87] A recent study detected 74 unique methylated CpG loci in the MHC region, with 22 genes containing 32 of these differentially methylated CpG motifs. Here, HLA-C is linked to rheumatoid arthritis.