[66, 129] In a recent study, examining DNA methylation patterns in whole blood from AD patients, differential methylation regions were identified in gene HOXB6, and abnormal hypermethylation of sites within HOXB6 (cg17179862 and cg03803541) affected granulocyte and monocyte production.[137] Even more intriguingly, the same CpG sites also exhibit different or even opposite methylation patterns in the brain and blood. Here, HOXB6 is linked to Alzheimer disease.