The pathways enriched in the high RS group were axon guidance (nominal p = 0.004, FDR = 0.196, NES = 1.58, gene size = 128), adherens junction (nominal p = 0.008, FDR = 0.248, NES = 1.67, gene size = 66), dilated cardiomyopathy (nominal p = 0.008, FDR = 0.162, NES = 1.66, gene size = 88), hypertrophic cardiomyopathy HCM (nominal p = 0.008, FDR = 0.221, NES = 1.66, gene size = 1.66), WNT signaling (nominal p = 0.008, FDR = 0.205, NES = 1.56, gene size = 146), and TGF‐beta signaling pathway (nominal p = 0.0097, FDR = 0.179, NES = 1.60, gene size = 81). The gene discussed is TGFB1; the disease is hypertrophic cardiomyopathy.