As a subunit of 19S regulatory particle in 26S proteasome, 26S proteasome non‐ATPase regulatory subunit 14 (PSMD14, also known as RPN11 and POH1), belongs to the JAB1/MPN+/MOV34 (JAMM) domain protease family of DUBs and has been reported to be involved in carcinogenesis and progression of several human cancers [8, 9, 10]. The gene discussed is PSMD14; the disease is cancer.