APOE and hyperlipidemia: An analysis of myeloid cell populations in Apoe−/− mice fed a Western diet showed no differences in monocyte subtypes and neutrophils after repeated injections of BMDM exosomes (Figure 2H), which could in part be due to overwhelming proliferative signaling caused by hyperlipidemia in this model (Swirski et al., 2007; Yvan-Charvet et al., 2010).