Furthermore, miR-486-5p was shown to reduce ABCA-1 expression in macrophages (Liu et al., 2016) that we reproduced through our studies of BMDM-HG-exo, which in this context could contribute to atherosclerosis acceleration in Apoe−/− mice treated with BMDM–HG-exo, and atherosclerosis in diabetic patients. Here, APOE is linked to atherosclerosis.