EZH2 and cancer: EZH2, a catalytic subunit of PRC2, is an oncogenic protein that silences the expression of various tumor-inhibitor miRNAs, such as miR-125b, miR-139-5p, miR-101, let-7c, and miR200b, and is typically increased in human cancers (Wang et al., 2016; Ma et al., 2018).