The therapeutic mechanism of CGA in liver fibrosis caused by schistosomiasis is also consistent with the aforementioned result, whereby significant downregulation of miR-21 expression is accompanied by upregulation of Smad7, reductions of p-Smad2 and p-Smad3, and conspicuous alleviation of fibrosis (Wang et al., 2017). Here, SMAD2 is linked to Hepatic fibrosis.