Yang et al. reported a novel modulatory mechanism of promoting renal fibrosis in which miR-199a-3p suppresses the suppressors of cytokine signaling-7 (SOCS7), a SOCS family, to upregulate STAT3 activation, which is directly induced by TGF-β-driven p53 upregulation. This evidence concerns the gene TGFB1 and renal fibrosis.