Furthermore, TBK1 (TANK-binding kinase 1) mediated phosphorylation of mutant Httex1 at S13 and S16 lowers its levels and results in a significant reduction in Httex1 aggregation and inclusion formation in different cellular models and a C. elegans model of HD (Hegde et al., 2020). Here, TBK1 is linked to Huntington disease.