Mutating both S13 and S16 to aspartate to mimic the phosphorylation was shown to reverse the pathology of mutant Htt in an HD mouse model (Gu et al., 2009) and modulate Htt aggregation in different cellular models (Mangiarini et al., 1996; Martindale et al., 1998; Scherzinger et al., 1999; Barbaro et al., 2015). The gene discussed is HTT; the disease is Huntington disease.