In addition, dysregulation of other pathways, such as regulation of apoptosis (Jordan, 2015; Ahmed et al., 2019), DNA damage checkpoints (Lord and Ashworth, 2012; del Rincón et al., 2014), and P53 signaling pathway (Silwal-Pandit et al., 2017), were also involved in cancer cell growth, proliferation, invasion, and metastasis and played crucial roles in BC cells. This evidence concerns the gene TP53 and breast cancer.