NOTCH4 and cancer: In the GSEA enrichment results, we noticed that genes highly expressed in the high-risk patients were significantly enriched in multiple cancer-related pathways, such as Notch4 signaling pathway (normalized enrichment score, NES = 1.937, size = 53), cell cycle regulation (NES = 1.866, size = 85), stabilization of P53 (NES = 1.806, size = 55), regulation of DNA damage checkpoints (NES = 1.917, size = 66), and apoptosis (NES = 1.951, size = 52) (p < 0.05 and FDR < 0.25) (Supplementary Figure S7).