In addition to the discovered NOD2, IL-23R, ATG16L1, IL-10R, IL-10, XIAP, etc. of IBD-related genes in European and American populations, recent studies have reported more new involvement in cell autophagy, immune regulation, intestinal mucosal barrier, etc. The total number of functional IBD-related sites has reached 200. The gene discussed is NOD2; the disease is inflammatory bowel disease.