WRN and Rothmund-Thomson syndrome: Of the five human RecQ families, three are genetically linked to cancer syndromes and premature diseases, such as Bloom’s syndrome (BLM gene mutations), Werner’s syndrome (WRN gene mutations), Rothmund-Thomson syndrome (RTS), RAPADILINO, and Baller-Gerold syndrome (caused by mutation of RECQ4) (Ellis et al., 1995; Yu et al., 1996; Kitao et al., 1999; Siitonen et al., 2003).