CXCL12 and malignant colon neoplasm: The result is consistent with previous studies that BRAF mutant MSI-H colon cancer is associated with the overexpression of stromal cell-derived factor-1 (SDF-1; also called CXCL12) and chemokine (C-X-C motif) receptor 4 (CXCR4), thereby suggesting chemokines like CXCR4 may serve as future therapeutic targets (Molina-Cerrillo et al., 2020).