Immunochemistry of tumor tissues of patients suggest that the expression levels of PD-1 (Figures 8A,B), PD-L1 (Figures 8C,D), CTLA-4 (Figures 8E,F), TIM-3 (Figures 8G,H), and LAG-3 (Figures 8I,J) are significantly higher in BRAF mutated samples than in BRAF wild-type samples. The gene discussed is BRAF; the disease is neoplasm.