However, in the context of HFD and genetically obese backgrounds (ob/ob), Fxr-deficient mice prevalently showed beneficial effects with regards to glucose homeostasis and obesity (Prawitt et al., 2011; Zhang et al., 2012; Parséus et al., 2017). The gene discussed is NR1H4; the disease is obesity due to melanocortin 4 receptor deficiency.