Previous studies also stated that miR-645 bound to downstream target mRNAs (EFNA5) to regulate CRC development (Li et al., 2020), and TGFBR2 could also be acted as a target of miR-135b and involved in CRC cell proliferation and apoptosis through the miR-135b/TGFBR2 pathway (Li et al., 2015). Here, EFNA5 is linked to colorectal carcinoma.