In patients with somatic cancers, by contrast, cancer cells expressing a high level of laminin and CD49f are associated with poor prognosis, high recurrence rates, and high incidence rates of cancer stem cells (Chang et al., 2012; Vieira et al., 2014), and the blockade of a laminin-411–Notch axis was shown to inhibit glioblastoma growth through tumor–microenvironment crosstalk (Sun et al., 2019). This evidence concerns the gene LAMB2 and cancer.