It has been shown that JNK activation mediates compensatory proliferation in parotid glands at day 5 post-IR (Wong et al., 2019) and PGE2-induced JNK signaling is able to stimulate proliferation of pulmonary epithelial tumor cells (Zhong et al., 2015) and human mesenchymal stem cells (Yun et al., 2011). Here, MAPK8 is linked to neoplasm.