Moreover, we have proposed the Bz+PTX combined therapy, showing that it was able to reduce parasitemia, reverse ECG alterations and expression of tumor necrosis factor (TNF) in heart tissue, and its type-1 receptor (TNFR1) on T cells, as well as inducible nitric oxide synthase (iNOS/NOS2) in cardiac tissue, and NO concentrations in serum. This evidence concerns the gene TNF and parasitic infectious disease.