IL2 and Cowden disease: IL-2, a broad pro-inflammatory cytokine studied in CD (Briceño and Mosca, 1996; Abel et al., 2001; Mengel et al., 2016), showed a significant increase upon T. cruzi infection (24.27 ± 8.76) when compared to the non-infected group (not-detected), which was partially abrogated after Bz (5.66 ± 4.28), PTX (6.90 ± 4.16), and Bz+PTX therapies (10.88 ± 8.24) (Figure 6B).