Interestingly, granzyme A+ CD8+ T lymphocytes were detected in cardiac lesions CD patients (Reis et al., 1993), and patients with advanced CCC show higher proportion of CD8+ cytotoxic T cells producing granzyme B and perforin than patients in early stages of the heart disease (Lasso et al., 2015), suggesting a dysfunctionality in T lymphocyte response as disease progresses (Mateus et al., 2019). Here, PRF1 is linked to heart disorder.