EHMT2 and infection: Next, we assessed the impact of H3K9 hypermethylation and autophagy inhibition on the intracellular survival of Mtb. We observed that, in contrast to the untreated cells, inhibition of G9a decreased the survival of intracellular MtbPrt 24 h after infection (Figure 3K; P ≤ 0.001); inhibition of autophagy further increased the survival of Mtbprt (Figure S3).