To explore CYP3A4 as a potential anti-cancer target, miR-4277 was identified via the online tool miRDB as a microRNA that could potentially target cyp3a4. The potential binding sites of miR-4277 in the 3′-UTR of cyp3a4 as well as in wild type cyp3a4 and cyp3a4 with mutated miR-4277 binding sites are shown in Figure 2A. This evidence concerns the gene CYP3A4 and cancer.