The results showed that ME2 overexpression in SW1783 and U251MG cells upregulated the expression of N-cadherin, vimentin, YKL40, and MET expression, whereas it downregulated the expression of E-cadherin and OLIG2, suggesting that ME2 promotes PMT of glioma cells (Figure 7A). This evidence concerns the gene CHI3L1 and glioma.