Previous data suggested that ER stress mediated UPR contributes to cancer metastasis, and TUSC3-deficiency enhanced UPR to promote metastatic potential of non-small cell lung cancer (NSCLC) (16), which encouraged us to investigate whether LncRNA MIR503HG inhibited GC metastasis in a UPR-dependent manner. This evidence concerns the gene TUSC3 and non-small cell lung carcinoma.