Finally, it is becoming clear that PHF6 plays a role in lineage plasticity of hematopoietic malignancies, as PHF6 mutations exist in T/Myeloid MPAL as well as MPAL, NOS (particularly B/T MPAL) and is frequently associated with early T-ALL which frequently shows myeloid marker expression. Here, PHF6 is linked to acute lymphoblastic leukemia.