PHF6 and acute lymphoblastic leukemia: Moreover, PHF6 KO B-ALL cells induced a malignancy closer in presentation to lymphoma than leukemia, with tumor cells showing reduced expression of CD19 and B220 and B-cell development genes (e.g., Cd74, IL4ra, Lyn, Ly86, and BLK), and upregulation of CD4 and T-cell signal transduction genes (69).