HIF1A and cancer: Therefore, the coexistence of three distinct cellular metabolic phenotypes is revealed in cancer cells: 1) glycolytic, characterized by high activity of HIF-1α and high activity of the glycolytic pathway; 2) OXPHOS state, characterized by high activity of AMPK and high activity of OXPHOS pathways such as glucose oxidation and fatty acid oxidation; 3) hybrid metabolic state, characterized by high activity of AMPK and HIF-1α and concomitant functioning of glycolysis and OXPHOS pathways.