WEE1 and neoplasm: Metabolic reprogramming during large intestine carcinogenesis is largely mediated by (a) altered expression of several oncogenes and a loss of tumor suppressor genes, encoding usually various transcriptional factors and protein kinases (30, 31), (b) adaptation to nutrient and oxygen availability in the local tumor microenvironment (metabolic plasticity) (32), and (c) metabolic cross-talk with stromal, adipose tissue and immune cells (31, 33–37).