speculated that the downregulation of GSDMD may regulate cell cycle-related proteins by activating ERK (extraCellular signal-regulated kinase), STAT3 (Signal Transducer and Activator of Transcription 3) and PI3K/AKT (phosphatidylinositol 3 kinase) signaling pathway, and promoted the S/G2 transition of gastric cancer cells. The gene discussed is AKT1; the disease is gastric cancer.