TNF and neoplasm: 1. Pyroptosis-related protein such as caspase-1, IL-1β, and Gasdermin-D are negatively correlated with the tumor grade, tumor size, clinical stage, death risk of breast cancer (Wu et al.);2. DHA (docosahexaenoic acid) can induce GSDMD-mediated pyroptosis of breast cancer cells (Nathalia et al.);3. Under hypoxic condition, nPD-L1 can switch TNFα-induced apoptosis to pyroptosis and GSDMC is cleaved by caspase8 in breast cancer cells (Hou et al.).