CD274 and breast carcinoma: At the same time, they also found that some chemotherapeutics such as daunorubicin, doxorubicin, epirubicin and actinomycin D could induce the expression of nPD-L1 (nuclear PD-L1) and GSDMC as well as the activation of caspase-8, inducing pyroptosis in MDA-MB-231 human breast cancer cells (55).