1. p53 can induce pyroptosis (Gao et al.);2. chemotherapeutic drug cisplatin can indue GSDME-mediated pyroptosis (Peng et al.);3. PPVI can active caspase-1 and turn apoptosis to pyroptosis of NSCLC cells through the ROS/NF-κB/NLRP3/GSDMD pathway (Teng JF et al.);4. Huaier extract can activate NLRP3 to induce pyroptosis and inhibit the development of NSCLC (Xie Jet al.). The gene discussed is CASP1; the disease is non-small cell lung carcinoma.