Studies have reported that pyroptosis-related protein caspase-1, NLRP3 and GSDMD were highly expressed in endometrial cancer tissue, and hydrogen could inhibit the growth of endometrial cancer by inducing GSDMD-mediated pyroptosis through a ROS/NLRP3/caspase-1 pathway (138). Here, NLRP3 is linked to endometrial cancer.