ESR2 and hepatocellular carcinoma: 1. The expression of NLRP3 and ASC in HCC tissues were significantly lower than paracancer tissues (Wei et al.);2. NLRP3 inflammasomes induce pyroptosis and inhibit autophagy through the E2/ERβ/AMPK/mTOR pathway (Wei et al.);3. AIF can inhibit the growth of HCC both in vitro and in vivo by inducing NLRP3-mediated pyroptosis (Zhang et al.);4. Euxanthone can inhibit the development of HCC by inducing pyroptosis (Chen et al.).