GSDMD and gastric cancer: 1. Caspase-3 was activated by 5-FU to induce GSDME-mediated pyroptosis in gastric cancer cell lines SGC-7901 and MKN-45 (Wang et al.);2. Knocking out GSDME in SGC-7901 cells can convert the pyroptosis into apoptosis after using BIX-01294 combined with cisplatin (Deng BB et al.);3. The expression of GSDMD in gastric cancer is lower than normal tissues (Wang et al.);4. A speculation that the downregulation of GSDMD may regulate cell cycle-related proteins by activating ERK, STAT3 and PI3K/AKT pathway, and promote the S/G2 transition of gastric cancer cells (Wang et al.).