Additionally, a study investigating the development of NSCLC resistance to EGFR-TKIs found that gefitinib-resistant NSCLC cells acquire metabolic flexibility characterized as a ligand-independent translocation of EGFR to mitochondria, which might contribute to the upregulation of mitochondrial function and capacity for OXPHOS (158). Here, EGFR is linked to non-small cell lung carcinoma.