Hypoxic microenvironment might inhibit the activation of AMPK targets, as well as apoptosis, by decreasing PGC-1α through SIRT1 deacetylation-dependent mechanisms; which may regulate the cytotoxic response to cisplatin and doxorubicin by licensing an apoptotic process controlled by mitochondria in NSCLC (66). Here, SIRT1 is linked to non-small cell lung carcinoma.