Investigation of the interplay between troglitazone and chemotherapeutic drugs (cisplatin or paclitaxel) in xenotransplantation models indicated that chemotherapeutic drugs can induce PPAR-γ; moreover, the authors identified a sequence-specific synergy between PPAR-γ ligands and chemotherapeutic agents in the treatment of lung cancer (143). The gene discussed is PPARG; the disease is lung carcinoma.