METTL3 and colorectal carcinoma: One study revealed that compared with normal tissues, the expression of METTL3 was higher in CRC, and with MeRIP-m6A-seq, they further noticed that the elevated m6A modification level increased the expression of SOX2 (which is required for stem-cell maintenance) via METTL3 interaction with IGF2BP2 to inhibit SOX2 degradation (44).