In their study, they reported a seven-gene signature, including WTAP, RBM15, YTHDF2, YTHDF1, and ALKBH5 as risk genes, for their expression levels, which were positively associated with increasing malignancy of glioma, whereas FTO and YTHDC1 were negatively correlated with increasing malignancy and were therefore protective genes. This evidence concerns the gene FTO and central nervous system cancer.