NFE2L2 and non-small cell lung carcinoma: A letter to the editor present a cohort of 69 patients from the Memorial Sloan Kettering Sequencing with KEAP1/NFE2L2 mutations who were treated with immunotherapy and demonstrated inferior survival compared with patients with KEAP1/NFE2L2 wild-type tumors (7).Similar results were also described in KEAP1 mutations of a prospective study with 66 NSCLC patients, which are unresponsive to immunotherapy (8).