HIF1A and breast cancer: Moreover, it inhibits the expression of the pro-angiogenic cell surface marker CD31, thereby disrupting endothelial tubulogenesis, thereby interrupting endothelial tubulogenesis, decreases the binding of HIF-1α to the HRE sequence in human BC cells and suppresses neovascularization in a chick chorioallantoic membrane and a Matrigel plug-implanted mouse model (47).