Salinomycin increases apoptosis by a decreased expression of Bcl-2; decreases the migration capacity accompanied by a decreased expression of c-Myc and Snail in MCF7 MS cells, and significantly reduces the tumor growth accompanied by decreased expression of the critical components of the Hedgehog pathway (PTCH, SMO, Gli1 and Gli2) in xenograft tumors. Here, PTCH1 is linked to neoplasm.