MAPT and tauopathy: It is noted that cryo-EM has thus far not identified different conformers from a single tauopathy, for which there may be many possibilities e.g. conformers may exist in smaller populations and may not be detected after data ‘averaging’, or a predominant conformer may be established by the end of aggregation and cryo-EM has thus far only been performed with end stage tau fibrils and not on soluble species.