MAPT and tauopathy: We have previously demonstrated the utility of Raman spectroscopy for distinguishing between aggregates formed from different proteins.24 However, given that different conformers of the same protein, in this case tau, are found in different tauopathies17 and possibly even in the same tauopathy,20,52 it is more important to demonstrate the conformational sensitivity of this methodology for discrimination of different tau conformers beyond distinguishing between monomer, oligomer or fibril of the same tau variant.