For example, phosphorylation of tau at serine-202, threonine-205 and serine-208, with the absence of phosphorylation at serine-262 leads to spontaneous aggregation of tau in vitro in the absence of cofactor.18 As well as being conformationally distinct, it has been shown that tau fibrils from AD and CBD have unique patterns of PTMs, suggesting that PTMs may be used as markers to identify tau conformers from different diseases.19,20. The gene discussed is MAPT; the disease is Alzheimer disease.