TFF1 and cancer: Overall GKN2 expression was positive in 6.67% and negative in 78% of cancers (p < 0.05, χ2 = 11.19, or χ2 = 27.35), and TFF1 was lost in 78.89% of cancers (p < 0.05, χ2 = 29.45, or χ2 = 23.42), comparing with distal gastric mucosa (normal gastric mucosa epithelium) or paracancerous tissue (intestinal metaplasia) as given in Table 2.