Figure 5 indicated that the T487 locus exhibits a higher phosphorylation level for breast cancer (P = 4.7e-8), colon cancer (P = 1.6e-12), UCEC (P = 5.9e-10), and LUAD (P = 10.7e-24) with normal tissues (Figure 5A), followed by no significant change of phosphorylation level of the T487 locus for ovarian cancer (P = 3.2e-1) (Figure 5B). Additionally, the potential association between the phosphorylation level of EZH2 and the clinical survival prognosis of cases with breast cancer and colon cancer were explored. We found that there was no significant difference (Figure 5C). Here, EZH2 is linked to malignant colon neoplasm.