Concentration of immune factors in breastmilk samples in the SARS-CoV-2–positive women depending on the presence or not of COVID-19-related symptoms did not show relevant differences, neither in the first sampling time (lower IL-12 in symptomatic than in asymptomatic women, p<0.01) nor in the second (higher IL-15 (p<0.01) and lower GM-CSF (p<0.03) in symptomatic women). This evidence concerns the gene IL15 and COVID-19.