These pathways are different in recognition of “bulky lesions”: In TCR, RNA polymerase II, CSA, and CSB (Cockayne syndrome proteins A and B) recognize the damage, while in GGR XPC (xeroderma pigmentosum group C)/UV excision repair protein Rad23B or DDB1 and DDB2 (DNA damage binding proteins 1 and 2) are recruited (50, 68). Here, DDB1 is linked to xeroderma pigmentosum.